Anti-Human IFN beta Functional Grade Purified

Description: The A1 monoclonal antibody reacts with human IFN-β. The A1 antibody is a neutralizing antibody. IFN-β is classified as a type I IFN which is a group of structurally and functionally related proteins demonstrating anti-viral, anti-parasitic, and anti-proliferative activities.

References: Coelho LF, Magno de Freitas Almeida G, Mennechet FJ, Blangy A, Uzé G. Interferon-alpha and -beta differentially regulate osteoclastogenesis: role of differential induction of chemokine CXCL11 expression. Proc. Nat. Acad. Sci. 2005 102: 11917-11922.

Diaz MO, Ziemin S, Le Beau MM, Pitha P, Smith SD, Chilcote RR, Rowley JD. Homozygous deletion of the alpha- and beta 1-interferon genes in human leukemia and derived cell lines. Proc. Nat. Acad. Sci. 1988 85: 5259-5263.

Shepard HM, Leung D, Stebbing N, Goeddel DV. A single amino acid change in IFN-beta1 abolishes its antiviral activity. Nature 1981 294: 563-567.