Anti-Human CD50 (ICAM-3) FITC

Description: Intercellular Adhesion Molecule-3 (ICAM-3) is a member of the immunoglobulin supergene family and functions as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1). ICAM-3 is a heavily glycosylated, integral membrane protein with five immunoglobulin-like domains. It shares high homology to ICAM-1 and ICAM-2 in the extracellular region. In contrast to ICAM-1 and ICAM-2, ICAM-3 is absent on endothelia. ICAM-3 is expressed on resting lymphocytes, monocytes and neutrophils, representing the major LFA-1 ligand on these cells. The finding that adhesion of resting T lymphocytes to LFA-1 occurs primarily via ICAM-3 combined with the fact that ICAM-3 is much better expressed than other LFA-1 ligands on monocytes and resting lymphocytes implies an important role for ICAM-3 in the initiation of immune responses.

Citations: Aldinucci,D.; Poletto,D.; Nanni,P.; Degan,M.; Rupolo,M.; Pinto,A.; Gattei,V.. CD40L induces proliferation, self-renewal, rescue from apoptosis, and production of cytokines by CD40-expressing AML... Experimental Hematology 2002;30:1283-1292. (Link)

Babina,Magda; Mammeri,Kerstin; Henz,Beate M.. Retinoic acid up-regulates myeloid ICAM-3 expression and function in a cell-specific fashion--evidence for retinoid signaling pathways in the mast cell lineage. Journal of Leukocyte Biology 2001;69:361-372. (Link)

Chatzimanolis,N.; Kraus,J.; Bauer,R.; Engelhardt,B.; Bregenzer,T.; Kuehne,B.S.; Tofighi,J.; Laske,C.; Stolz,E.; Blaes,F.; Voigt,K.; Traupe,H.; Kaps,M.; Oschmann,P.. CD45RA+ ICAM-3+ lymphocytes in interferon-beta1b-treated and -untreated patients with relapsing-remitting multiple sclerosis. Acta Neurologica Scandinavica 2004;110:377-385. (Link)