Description: BMS109 does not cross react with mouse.
Intercellular Adhesion Molecule-2 (ICAM-2) is a 60 kDa surface
glycoprotein that promotes adhesion between immune cells and the
vascular endothelium. ICAM-2 is a member of the Ig-superfamily with
two immunoglobulin-like extracellular domains. ICAM-2 is much more
closely related to the two N-terminal domains of ICAM-1 (34% identity)
than either ICAM-1 or ICAM-2 is to other members of the Ig-superfamily,
demonstrating the existence of a subfamily of Ig-like ligands that bind
the same integrin receptor. ICAM-2 is broadly distributed on
hematopoietic cells. On resting lymphocytes, the ICAM-2 expression is
several-fold higher than that seen with ICAM-1, while monocytes
express equivalent levels of ICAM-1 and ICAM-2. In contrast to ICAM-1,
neutrophils stain negative for ICAM-2. Just little or no ICAM-2 staining
can be demonstrated on other cell lines, the sole exception being
resting vascular endothelial cells, which possess high levels of ICAM-2,
and small clusters of cells in lymphoid tissue germinal centres.
ICAM-2 expression is unaffected by a variety of inflammatory cytokines.