Anti-Human CD54 (ICAM-1) Purified

Description: Recognizes the D1 domain of human CD54.

Intercellular Adhesion Molecule-1 (ICAM-1) is a member of the immunoglobulin supergene family and functions as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1), an alpha-betacomplex that is a member of the leukocyte integrin family of cell-cell and cell-matrix receptors.

ICAM-1 is a single-chain glycoprotein with a polypeptide core of 55 kD that can be expressed on non-hematopoietic cells of many lineages such as vascular endothelial cells, thymic epithelial cells, other epithelial cells and fibroblasts and on hematopoietic cells such as tissue macrophages, mitogen-stimulated T-lymphoblasts, germinal center B cells and dendritic cells in tonsils, lymph nodes and Peyer's patches.

ICAM-1 is inducible on fibroblasts and endothelial cells by inflammatory mediators such as IL-1, TNF and IFN-gamma within few hours and is correlated to the infiltration of lymphocytes into inflammatory lesions. ICAM-1 seems to be the initial marker of inflammatory reactions and is expressed prior to, and to a greater extent than is HLA-DR.

sICAM-1 serum levels were found elevated in acute renal graft rejection, insulin-dependent diabetis mellitus, anterior uveitis and in allergic inflammation.

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Vandermeeren,Marc; Janssens,Sophie; Wouters,Hilde; Borghmans,Inge; Borgers,Marcel; Beyaert,Rudi; Geysen,Johan. Dimethylfumarate is an Inhibitor of Cytokine-Induced Nuclear Translocation of NF-[kappa]B1, But Not RelA in Normal Human Dermal Fibroblast Cells. Journal of Investigative Dermatology 2001;116:124-130. (Link)

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