Anti-Human HLA-DR Biotin

Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. HLA-DR is a heterodimeric transmembrane protein composed of α and β subunits and plays an important role in the presentation of peptides to CD4⁺ T lymphocytes.

References: Fullen, D. R. and J. T. Headington. 1998. Factor XIIIa-positive dermal dendritic cells and HLA-DR expression in radial versus vertical growth-phase melanomas. J Cutan Pathol. 25(10): 553-8.

Hua, Z. X., K. E. Tanaka, et al. 1998. Immunoreactivity for LN2 and LN3 distinguishes small cell carcinomas from non-small cell carcinomas in the lung. Hum Pathol. 29(12): 1441-6.

Ioachim, H. L., S. E. Pambuccian, et al. 1996. Lymphoid monoclonal antibodies reactive with lung tumors. Diagnostic applications. Am J Surg Pathol. 20(1): 64-71.

Davey, F. R., S. Olson, et al. 1988. The immunophenotyping of extramedullary myeloid cell tumors in paraffin-embedded tissue sections. Am J Surg Pathol. 12(9): 699-707.

Norton, A. J. and P. G. Isaacson. 1987. Detailed phenotypic analysis of B-cell lymphoma using a panel of antibodies reactive in routinely fixed wax-embedded tissue. Am J Pathol. 128(2): 225-40.