Anti-Human HLA-BC APC

Description: This B1.23.2 monoclonal antibody recognizes the human Human Leukocyte Antigens (HLA) B and C. Along with HLA-A, these proteins correspond to MHC Class I in humans. HLA-B and HLA-C are expressed on nearly all cell types and heterodimerize with beta-2 microglobulin at the cell surface. These molecular complexes play a critical role in the presentation of endoplasmic reticulum-derived peptides to immune cells.

References: Desfrançois J, Moreau-Aubry A, Vignard V, Godet Y, Khammari A, Dréno B, Jotereau F, Gervois N. Double positive CD4CD8 alphabeta T cells: a new tumor-reactive population in human melanomas. PLoS One. 2010 Jan 5;5(1):e8437. (B1.23.2, FC)

Srivastava R, Duceman BW, Biro PA, Sood AK, Weissman SM. Molecular organization of the class I genes of human major histocompatibility complex. Immunol Rev. 1985 Jul;84:93-121. Review.

Rebaï N, Malissen B. Structural and genetic analyses of HLA class I molecules using monoclonal xenoantibodies. Tissue Antigens. 1983 Aug;22(2):107-17. (B1.23.2)