Human GM-CSF Recombinant Protein Carrier-Free

Also known as: Granulocyte/Macrophage-Colony Stimulating Factor

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 34-8339

Cat. No. Size
34-8339-82 100 ug
34-8339-85 500 ug
Please inquire about custom configurations or bulk packaging.

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Data for Human GM-CSF Recombinant Protein Carrier-Free.

Description

Description: Human GM-CSF (Granulocyte/Monocyte-Colony Stimulating Factor) is a differentially glycosylated factor produced mainly by activated T cells and macrophages. Endothelial cells and fibroblasts can also produce GM-CSF after exposure to TNF alpha, IL-1, IL-2 and IFN gamma. GM-CSF is found associated with extracellular matrix and in membrane-bound formats too. GM-CSF stimulates proliferation, activation and differentiation of macrophages and granulocytes and their progenitors.

Details
Reactivity Human
Purity Greater than or equal to 95%, as determined by SDS-PAGE
Molecular Mass The protein is not methionylated at the N-terminal and has a predicted molecular mass of 14,478. The DTT reduced protein migrates as a 14 kDa polypeptide on SDS-PAGE. The non-reduced protein migrates as a 13 kDa polypeptide.
Endotoxin Level Less than 0.01 ng/ug cytokine as determined by the LAL assay.
Reported Applications ELISA, Cytokine Bioassays
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
39-8339 Human GM-CSF Single-Use ELISA RSG Standard ELISA RUO
14-8339 Human GM-CSF Recombinant Protein ELISA, FA RUO
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14-1169 Anti-Human CD116 Purified FC RUO
References

References: Park BK, Zhang H, Zeng Q, Dai J, Keller ET, Giordano T, Gu K, Shah V, Pei L, Zarbo RJ, McCauley L, Shi S, Chen S, Wang CY. NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF. Nat Med. 2007 Jan;13(1):62-9.

Dranoff G, Crawford AD, Sadelain M, Ream B, Rashid A, Bronson RT, Dickersin GR, Bachurski CJ, Mark EL, Whitsett JA. Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science. 1994 Apr 29;264(5159):713-6.

Grabstein KH, Urdal DL, Tushinski RJ, Mochizuki DY, Price VL, Cantrell MA, Gillis S, Conlon PJ. Induction of macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor. Science. 1986 Apr 25;232(4749):506-8.