Human Glial Cell Derived Neurotrophic Factor (GDNF) Recombinant Protein

Description: Glial Cell derived Neurotrophic Factor (GDNF), a member of the TGFß superfamily, is a neurotrophic factor that promotes the survival of various neuronal populations in both the central and peripheral nervous systems during their development. Neuronal subpopulations affected by GDNF include motor neurons, midbrain dopaminergic neurons and Purkinje cells. GDNF is conserved across mammalian species with human and rat orthologs sharing approximately 93% amino acid sequence identity. E. coli-produced recombinant human GDNF is a disulfide-linked, non-glycosylated homodimer composed of two 135 amino acid polypeptides.

References: Anitha, M. Gondha, C. Sutliff, R. Parsadanian, A. Mwangi, S. Sitaraman, S. V. Srinivasan, S. GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathway. J. Clin. Invest. 2006; 116: 344-356.

Boucher, T. J. Okuse, K. Bennett, D. L. H. Munson, J. B. Wood, J. N. McMahon, S. B. Potent analgesic effects of GDNF in neuropathic pain states. Science 2000; 290: 124-127.

Gash, D. M. Zhang, Z. Ovadia, A. Cass, W. A. Yi, A. Simmerman, L. Russell, D. Martin, D. Lapchak, P. A. Collins, F. Hoffer, B. J. Gorhardt, G. A. Functional recovery in parkinsonian monkeys treated with GDNF. Nature 1996; 380: 252-255.