Anti-Human FCRLA (FREB) Purified

Description: The N28.1 monoclonal antibody recognizes the Fc receptor homolog expressed in B cells (FREB), also know as FCRLA or FcRX. FREB is a member of the family of Fc receptors for IgG (FcRg). Unlike FcRg, FREB lacks a transmembrane sequence and has an intracellular localization. FREB has been detected in proliferating and activated B cells, EBV-transformed B cells, germinal center centroblast, follicular lymphoma and the Burkitt's lymphoma cell line Raji. In contrast with published reports, the N28.1 antibody was also able to detect expression of FREB in resting B cells from normal human blood samples.

References: Davis RS. Fc receptor-like molecules. Annu Rev Immunol. 2007;25:525-60.

Bohen SP, Troyanskaya OG, Alter O, Warnke R, Botstein D, Brown PO, Levy R.Variation in gene expression patterns in follicular lymphoma and the response to rituximab. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1926-30.

Davis RS, Li H, Chen CC, Wang YH, Cooper MD, Burrows PD. Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells. Int Immunol. 2002 Sep;14(9):1075-83.

Facchetti F, Cella M, Festa S, Fremont DH, Colonna M. An unusual Fc receptor-related protein expressed in human centroblasts. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3776-81. Epub 2002 Mar 12. (N28.1, FC, IHC, Pubmed)

Mechetina LV, Najakshin AM, Volkova OY, Guselnikov SV, Faizulin RZ, Alabyev BY, Chikaev NA, Vinogradova MS, Taranin AV.FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features.Eur J Immunol. 2002 Jan;32(1):87-96.