Anti-Human Foxp1 Purified

Description: This JC12 monoclonal antibody reacts with human Foxp1, a member of the Forkhead family of winged helix transcription factors. Foxp1 is expressed in nearly every human tissue, including lymphoid (e.g. tonsil, spleen, and thymus), epithelium, kidney, blood, and motor neurons. Altered Foxp1 expression has been observed in, among others, cancers of the breast, lung, colon, prostate, and pancreas. Moreover, patients with diffuse large B cell lymphomas express high levels of Foxp1, which can be utilized as a prognostic marker for survival. Finally, Foxp1 has been reported to be involved in early B cell development (i.e. pro-B cell to pre-B cell transition) and motor neuron specification and connectivity.

References: Arrber S. FoxP1: conducting the Hox symphony in spinal motor neurons. Nat Neurosci. 2008 Oct;11(10):1122-4. Review.

Hu H, Wang B, Borde M, Nardone J, Maika S, Allred L, Tucker PW, Rao A. Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol. 2006 Aug;7(8):819-26.

Banham AH, Connors JM, Brown PJ, Cordell JL, Ott G, Sreenivasan G, Farinha P, Horsman DE, Gascoyne RD. Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma. Clin Cancer Res. 2005 Feb 1;11(3):1065-72.

Banham AH, Beasley N, Campo E, Fernandez PL, Fidler C, Gatter K, Jones M, Mason DY, Prime JE, Trougouboff P, Wood K, Cordell JL. The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p. Cancer Res. 2001 Dec 15;61(24):8820-9. (JC12, WB, IHC, Pubmed)