FMC7 eFluor® 450

Clone: FMC7

Analyte Specific Reagent (ASR): Analytical and performance characteristics are not established.

SKU# 8048-0206

Cat. No.	Size
8048-0206-025	25 tests
8048-0206-120	120 tests

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Description

Description: The FMC7 monoclonal antibody recognizes a membrane glycoprotein that is expressed on mature human B lymphocytes. FMC7 recognizes a conformational epitope on the CD20 molecule that is exposed on a subset of mature B lymphocytes. The expression of this epitope has been shown to be extremely sensitive to levels of membrane cholesterol.

Details

Host	Mouse
Isotype	IgM
Reactivity	Human
Conjugate	eFluor 450
Laser	Violet Laser
Emit	450 nm
Excite	405 nm

Documentation

For complete product information, please download the TDS or IFU document.

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
8011-0206	FMC7 FITC	488 nm	518 nm		ASR

References

References: Brooks, DA, et al. Human lymphocyte markers defined by antibodies derived from somatic cell hybrids. IV. A monoclonal antibody reacting specifically with a subpopulation of human B lymphocytes. Journal of Immunology. 1981;126:1373-1377.

Serke, S, et al. Monoclonal antibody FMC7 detects a conformational epitope on the CD20 molecule: evidence from phenotyping after rituxan therapy and transfectant cell analyses.Cytometry. 2001;46:98-104.

Polyak, MJ, et al. A cholesterol-dependent CD20 epitope detected by the FMC7 antibody. Leukemia. 2003;17:1384-1389.

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Antigens	Cell Type	Formats
FMC7	B Cells	eFluor 450