Anti-Human Fc epsilon Receptor I alpha (FceR1) Purified

Description: The AER-37 monoclonal antibody reacts with the FcεRIα subunit, an IgE-binding subunit lacking signal-transducing ability. FcεRIα is expressed on mast and basophil cells and is upregulated by the presence of IgE. FcεRIα forms a tetrameric complex with one β and two γ subunits. The β and γ subunits possess immunoreceptor tyrosine-based activation motifs (ITAM). The FcεRI complex plays an important role in triggering IgE-mediated allergic reactions.

References:
Hakimi J., C. Seals, J. A. Kondas, L. Pettine, W. Danho, J. Kochan. (1990) The Alpha Subunit of the Human IgG Receptor (FceRI) is Sufficient for High-Affinity IgE Binding. J Biol Chem 265(36):22079-81

Hasegawa S, Pawankar R, Suzuki K, Nakahata T, Furukawa S, Okumura K, Ra C. (1999) Functional expression of the high affinity receptor for IgE (FcepsilonRI) in human platelets and its' intracellular expression in human megakaryocytes. Blood 93(8):2543-51.

Hasegawa M, Nishiyama C, Nishiyama M, Akizawa Y, Takahashi K, Ito T, Furukawa S, Ra C, Okumura K, Ogawa H. (2003) Regulation of the human Fc(epsilon)RI alpha-chain distal promoter. J Immunol 170(7):3732-8.

Yamaguchi M, Sayama K, Yano K, Lantz CS, Noben-Trauth N, Ra C, Costa JJ, Galli SJ. IgE enhances Fc epsilon receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fc epsilon receptor I expression and mediator release.J Immunol. 1999 May 1;162(9):5455-65. (AER-37, FC, PubMed)

Suzukawa M, Hirai K, Iikura M, Nagase H, Komiya A, Yoshimura-Uchiyama C, Yamada H, Ra C, Ohta K, Yamamoto K, Yamaguchi M. IgE- and FcepsilonRI-mediated migration of human basophils.Int Immunol. 2005 Sep;17(9):1249-55. (AER-37, FA, PubMed)

Ra C, Kuromitsu S, Hirose T, Yasuda S, Furuichi K, Okumura K. Soluble human high-affinity receptor for IgE abrogates the IgE-mediated allergic reaction.Int Immunol. 1993 Jan;5(1):47-54.