Anti-Human Fc epsilon Receptor I alpha (FceR1) APC

Description: The AER-37 monoclonal antibody reacts with the Fc epsilon RI alpha subunit, an IgE-binding subunit lacking signal-transducing ability. Fc epsilon RI apha is expressed on mast and basophil cells and is upregulated by the presence of IgE. Fc epsilon RI alpha forms a tetrameric complex with one beta and two gamma subunits. The beta and gamma subunits possess immunoreceptor tyrosine-based activation motifs (ITAM). The Fc epsilon RI complex plays an important role in triggering IgE-mediated allergic reactions.

References: Suzukawa M, Hirai K, Iikura M, Nagase H, Komiya A, Yoshimura-Uchiyama C, Yamada H, Ra C, Ohta K, Yamamoto K, Yamaguchi M. IgE- and FcepsilonRI-mediated migration of human basophils. Int Immunol. 2005 Sep;17(9):1249-55. (AER-37, FA, PubMed)

Hasegawa M, Nishiyama C, Nishiyama M, Akizawa Y, Takahashi K, Ito T, Furukawa S, Ra C, Okumura K, Ogawa H. Regulation of the human Fc(epsilon)RI alpha-chain distal promoter. J Immunol 2003. 170(7):3732-8.

Yamaguchi M, Sayama K, Yano K, Lantz CS, Noben-Trauth N, Ra C, Costa JJ, Galli SJ. IgE enhances Fc epsilon receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fc epsilon receptor I expression and mediator release. J Immunol. 1999 May 1;162(9):5455-65. (AER-37, FC, PubMed)

Hasegawa S, Pawankar R, Suzuki K, Nakahata T, Furukawa S, Okumura K, Ra C. Functional expression of the high affinity receptor for IgE (FcepsilonRI) in human platelets and its' intracellular expression in human megakaryocytes. Blood 1999. 93(8):2543-51.

Ra C, Kuromitsu S, Hirose T, Yasuda S, Furuichi K, Okumura K. Soluble human high-affinity receptor for IgE abrogates the IgE-mediated allergic reaction. Int Immunol. 1993 Jan;5(1):47-54.

Hakimi J., C. Seals, J. A. Kondas, L. Pettine, W. Danho, J. Kochan. The Alpha Subunit of the Human IgG Receptor (FceRI) is Sufficient for High-Affinity IgE Binding. J Biol Chem 1990. 265(36):22079-81