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Anti-Human Desmoglein 2 Purified

Also known as: DSG2, ARVC10, ARVD10, CDHF5, CMD1BB, HDGC

Clone: CSTEM28

RUO: For Research Use Only. Not for use in diagnostic procedures.

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SKU# 14-9159

Cat. No. Size
14-9159-80 25 ug
14-9159-82 100 ug

Data for Anti-Human Desmoglein 2 Purified.

Staining of a mixture of iPSC and the C2C12 cell line with 0.25 ug of Mouse IgG2b K Isotype Control...View More

  • Data for Anti-Human Desmoglein 2 Purified.
  • Data for Anti-Human Desmoglein 2 Purified.
Description

Description: This monoclonal antibody CSTEM28 reacts with human desmoglein 2 (DSG2), a type 1 transmembrane protein belonging to the cadherin family. DSG2 is expressed by epithelial cells, cardiomyocytes, endothelial progenitors, and CD34+CD45dim hematopoietic stem and progenitor cells. This adhesion molecule forms cell-cell adhesion complexes called desmosomes that provide tensile strength to tissues that experience mechanical stress. Other than its role in desmosome formation, DSG2 plays a role in barrier integrity, adhesion, migration, cell apoptosis, proliferation, vasculogenic mimicry, and intracellular signaling. DSG2-expressing endothelial progenitor cells are pro-angiogenic, suggesting a role in vasculature formation. On hematopoietic stem and progenitor cells, DSG2 expression is highest on CD38-CD90+ multi-potent cells. DSG2 expression is progressively decreased as a function of differentiation, with DSG2 expression absent on mature lymphocytes. DSG2 also serves as a receptor for adenoviruses and can be shed by mucosal barriers in the intestine.

Details
Host Mouse
Isotype IgG2b, kappa
Reactivity Human
Conjugate Purified
Reported Applications Flow Cytometric Analysis, Immunocytochemistry
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
12-9159 Anti-Human Desmoglein 2 PE 488 - 561 nm 578 nm FC RUO
53-9159 Anti-Human Desmoglein 2 Alexa Fluor® 488 488 nm 519 nm FC, ICC RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
12-4010 F(ab')2 Anti-Mouse IgG PE 488 - 561 nm 578 nm FC RUO
00-4958 Fluoromount-G™ ICC, IHC GPR
14-4732 Mouse IgG2b K Isotype Control Purified FC, ICC, IHC RUO
00-4959 Fluoromount-G™, with DAPI ICC, IHC RUO
00-4953 IHC /ICC Blocking Buffer - Low Protein ICC, IHC, IHC-F, IHC-P GPR
00-6993 7-AAD Viability Staining Solution FC GPR
50-4010 F(ab')2 Anti-Mouse IgG eFluor® 660 633 - 647 nm 668 nm FC, ICC, IHC RUO
References

References: Ebert LM, Tan LY, Johan MZ, Min KK, Cockshell MP, Parham KA, Betterman KL, Szeto P, Boyle S, Silva L, Peng A, Zhang Y, Ruszkiewicz A, Zannettino AC, Gronthos S, Koblar S, Harvey NL, Lopez AF, Shackleton M, Bonder CS. A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis. Angiogenesis. 2016 Oct;19(4):463-86

Tan LY, Mintoff C, Johan MZ, Ebert BW, Fedele C, Zhang YF, Szeto P, Sheppard KE, McArthur GA, Foster-Smith E, Ruszkiewicz A, Brown MP, Bonder CS, Shackleton M, Ebert LM. Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome. Oncotarget. 2016 Jun 22

Overmiller AM, McGuinn KP, Roberts BJ, Cooper F, Brennan-Crispi DM, Deguchi T, Peltonen S, Wahl JK 3rd, Mahoney MG. c-Src/Cav1-dependent activation of the EGFR by Dsg2. Oncotarget. 2016 Jun 21;7(25):37536-37555.

Kamekura R, Nava P, Feng M, Quiros M, Nishio H, Weber DA, Parkos CA, Nusrat A. Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier. Mol Biol Cell. 2015 Sep 15;26(18):3165-77.


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