Human Connective Tissue Growth Factor (CTGF) Recombinant Protein

Description: Connective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial cells. CTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. CTGF plays important roles in the proliferation and differentiation of chondrocytes, induces angiogenesis, and promotes cell adhesion in fibroblasts, endothelial, and epithelial cells.

References: Fonseca, C. Lindahl, G. E. Ponticos, M. Sestini, P. Renzoni, E. A. Holmes, A. M. Spagnolo, P. Pantelidis, P. Leoni, P. McHugh, N. Stock, C. J. Shi-Wen, X. Denton, C. P. Black, C. M. Welsh, K. I. du Bois, R. M. Abraham, D. J. A polymorphism in the CTGF promoter region associated with systemic sclerosis. New Eng. J. Med. 2007; 357: 1210-1220.

Nakanishi, T. Yamaai, T. Asano, M. Nawachi, K. Suzuki, M. Sugimoto, T. Takigawa, M. Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism. Biochem. Biophys. Res. Commun. 2001; 281: 678-681.

Kim, H.-S. Nagalla, S. R. Oh, Y. Wilson, E. Roberts, C. T., Jr. Rosenfeld, R. G. Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily. Proc. Nat. Acad. Sci. 1997; 94: 12981-12986.

Bradham, D. M. Igarashi, A. Potter, R. L. Grotendorst, G. R. Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J. Cell Biol.1991; 114: 1285-1294.