Anti-Human Collagen Type IV Purified

Description: This monoclonal antibody 1042 recognizes human collagen Type IV. Collagens are the main components of the extracellular matrix and provide the tensile strength to tissues. There are four main types of collagen (I, II, III and IV) which contribute to the connective tissue. Expression of type IV is restricted to the basal lamina. It contains two alpha-1 and one alpha-2-like chains. Collagen Type IV is associated with disorders such as Alport syndrome and Goodpasture's syndrome.

References: Hewitt RE, Powe DG, Morrell K, Bailey E, Leach IH, Ellis IO, Turner DR Laminin and collagen IV subunit distribution in normal and neoplastic tissues of colorectum and breast J Cancer. 1997; 75(2): 221–229. (1042, IHC frozen)

Schlingemann RO, Rietveld FJR, Kwaspen F, van de Kerkhof PCM, de Waal RMW, Ruiter DJ. Differential Expression of Markers for Endothelial Cells, Pericytes, and Basal Lamina in the Microvasculature of Tumors and Granulation Tissue American Am J Pathol. 1991 June; 138(6): 1335–1347.

Havenith MG, Cleutjens JPM, Beek C, Linden EVD, Goeij AFPM, Bosman FT. Human specific anti-type IV collagen monoclonal antibodies, characterization and immunohistochemical application. Histochemistry and Cell Biology 1987, 87 (2): 123-128. (1042, mAb characterization)