Anti-Human Clec12A PE

Description: This HB3 monoclonal antibody reacts with human Clec12A, which is also known as Myeloid Inhibitory C-type Lectin-like receptor (MICL). Clec12A is a highly glycosylated transmembrane receptor with a cytoplasmic ITIM that associates with SHP1 and SHP2. Clec12A is expressed mainly on granulocytes, monocytes, macrophages, and dendritic cells, including plasmacytoid dendritic cells. Expression of Clec12A on NK cells remains controversial. Although the function of Clec12A is not fully understood, studies suggest that this receptor plays a role in inflammation and LPS activation.

References: Larsen HO, Roug AS, Just T, Brown GD, Hokland P. Expressin of the hMICL in acute myeloid leukemia – a highly reliable disease marker at diagnosis and during follow-up. Cytometry Part B: Clinical Cytometry. doi: 10.1002/cyto.b.20614.

Lahoud MH, Proietto AI, Ahmet F, Kitsoulis S, Eidsmo L, Wu L, Sathe P, Pietersz S, Chang HW, Walker ID,Maraskovsky E, Braley H, Lew AM, Wright MD, Heath WR, Shortman K, Caminschi I. The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses. J Immunol. 2009 Jun 15;182(12):7587-94.

Marshall AS, Willment JA, Pyz E, Dennehy KM, Reid DM, Dri P, Gordon S, Wong SY, Brown GD. Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation. Eur J Immunol. 2006 Aug;36(8):2159-69. (HB3, FC)

Marshall AS, Willment JA, Lin HH, Williams DL, Gordon S, Brown GD. Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes. J Biol Chem. 2004 Apr 9;279(15):14792-802.