Anti-Human Cep55 Purified

Description: The monoclonal antibody EMRC10-11-55 recognizes the human centrosomal protein (Cep55). Cep55 is a 55 kDa microtubule-bundling protein that is found throughout the cell but specifically localizes to the mitotic spindle during metaphase and the midbody during anaphase. Cep55 is necessary for the completion of cytokenesis, a process that if disregulated promotes tumorigenesis via a mechanism of aneuploidy and chromosomal instablility. Cep55 is downstream of the transcription factor FOXM1, and has been found to be overexpressed in a head and neck squamous cell carcinoma (HNSCC), hepatocellular carcinoma, breast cancer, colorectal carcinoma (CRC), and in secondary metastatic sites. Expression has been found to correlate with severity of disease and as a cancer biomarker is prognostic of poor outcome in breast cancer. Cep55 is expressed at very modest levels in normal tissue, but is more prominent in testis and thymus.

References: Inoda S, Morita R, Hirohashi Y, Torigoe T, Asanuma H, Nakazawa E, Nakatsugawa M, Tamura Y, Kamiguchi K, Tsuruma T, Terui T, Ishitani K, Hashino S, Wang Q, Greene MI, Hasegawa T, Hirata K, Asaka M, Sato N. The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma. Exp Mol Pathol. 2011 90(1):55-60.

Inoda S, Hirohashi Y, Torigoe T, Nakatsugawa M, Kiriyama K, Nakazawa E, Harada K, Takasu H, Tamura Y, Kamiguchi K, Asanuma H, Tsuruma T, Terui T, Ishitani K, Ohmura T, Wang Q, Greene MI, Hasegawa T, Hirata K, Sato N. Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma. J Immunother. 2009 32(5):474-85.