Anti-Human CD98hc FITC

Description: The monoclonal antibody 5E5 recognizes human CD98hc protein also called CD98 heavy chain, FRP-1 (fusion regulatory protein-1 ) or 4F2. CD98 is a disulfide-linked complex composed of a heavy chain (a Type II membrane protein) and a light chain of which there are more than six different chains (LAT1, LAT2, y+LAT1, y+LAT2, Asc-1, xCT). CD98 can associate directly or indirectly with β 1 integrins, EpCAM and CD147 (EMMPRIN). The function of CD98 is thought to involve amino acid transport, cell fusion concomitantly with increased plasma membrane expression and integrin mediated adhesion. Expression of CD98 is broad including non-hematopoietic cells. In peripheral blood cells, monocytes expression is high while lymphocytes have intermediate levels and granulocytes express very little.

References: Haynes BF, Hemler ME, Mann DL, Eisenbarth GS, Shelhamer J, Mostowski HS, Thomas CA, Strominger JL, Fauci AS. Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes.J Immunol. 1981 Apr;126(4):1409-14.

Dalton P, Christian HC, Redman CW, Sargent IL, Boyd CA. Differential effect of cross-linking the CD98 heavy chain on fusion and amino acid transport in the human placental trophoblast (BeWo) cell line.Biochim Biophys Acta. 2007 Mar;1768(3):401-10.

Xu D, Hemler ME.Metabolic activation-related CD147-CD98 complex.Mol Cell Proteomics. 2005 Aug;4(8):1061-71