Anti-Human CD8a PE-Cyanine7

Also known as: CD8 alpha, leu-2a

Clone: SK1

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 25-0087

Cat. No.	Size
25-0087-41	25 tests
25-0087-42	100 tests
Please inquire about custom configurations or bulk packaging.

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Staining of normal human peripheral blood cells with Anti-Human CD19 eFluor® 450 (cat. 48-0199) and...View More

Description

Description: The SK1 monoclonal antibody reacts with the human CD8a molecule, an approximately 32-34 kDa cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T-cell development and activation of mature T cells.

Details

Host	Mouse
Isotype	IgG1, kappa
Reactivity	Human
Conjugate	PE-Cyanine7
Laser	Blue Laser, Green Laser, Yellow-Green Laser
Emit	775 nm
Excite	488 - 561 nm
Legal	FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT # 5,268,486, 5,569,587 AND 5,627,027 AND FOREIGN EQUIVALENTS AND PENDING APPLICATIONS. \\\\THIS MATERIAL IS SUBJECT TO PROPRIETARY RIGHTS OF GE HEALTHCARE BIO-SCIENCES CORP. AND CARNEGIE MELLON UNIVERSITY AND MADE AND SOLD UNDER LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. THIS PRODUCT IS LICENSED FOR SALE ONLY FOR RESEARCH. IT IS NOT LICENSED FOR ANY OTHER USE. THERE IS NO IMPLIED LICENSE HEREUNDER FOR ANY COMMERCIAL USE.\\\\COMMERCIAL USE shall include:\\1. sale, lease, license or other transfer of the material or any material derived or produced from it;\\2. sale, lease, license or other grant of rights to use this Material or any material derived or produced from it;\\2. use of this material to perform services for a fee for third parties.\\\\IF YOU REQUIRE A COMMERCIAL LICENSE TO USE THIS MATERIAL AND DO NOT HAVE ONE, RETURN THIS MATERIAL, UNOPENED TO EBIOSCIENCE, INC. 10255 SCIENCE CENTER DRIVE, SAN DIEGO, CALIFORNIA 92121 USA AND ANY MONEY PAID FOR THE MATERIAL WILL BE REFUNDED.
Reported Applications	Flow Cytometric Analysis

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
46-0087	Anti-Human CD8a PerCP-eFluor® 710	488 nm	710 nm	FC	RUO
47-0087	Anti-Human CD8a APC-eFluor® 780	633 - 647 nm	780 nm	FC	RUO
17-0087	Anti-Human CD8a APC	633 - 647 nm	660 nm	FC	RUO
11-0087	Anti-Human CD8a FITC	488 nm	518 nm	FC	RUO
12-0087	Anti-Human CD8a PE	488 - 561 nm	575 nm	FC	RUO
48-0087	Anti-Human CD8a eFluor® 450	405 nm	450 nm	FC	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
25-4714	Mouse IgG1 K Isotype Control PE-Cyanine7	488 - 561 nm	775 nm	FC	RUO
48-0199	Anti-Human CD19 eFluor® 450	405 nm	450 nm	FC	RUO

References

References: Campanelli, R., Palermo, B., et al. Human CD8 co-receptor is strictly involved in MHC-peptide tetramer-TCR binding and T cell activation. International Immunology. 2002 May; 14(1):39-44.

Evans, R.L., Wall, D.W., et al. Thymus-dependent membrane antigens in man: Inhibition of cell-mediated lympholysis by monoclonal antibodies to TH2 antigen. Immunol. 1981 Jan; 78,1:544-548.

View More Products

Antigens	Area of Biology	Cell Type	Formats
CD8	Adaptive Immunity	Dendritic Cells NK & NKT Cells T Cells	PE-Cyanine7