CD79b PerCP-eFluor® 710

Description: The CB3-1 monoclonal antibody reacts with human CD79b, the B cell antigen receptor Ig-beta chain. Together with the Ig-alpha chain, also known as CD79a, this cell surface molecule forms a heterodimeric complex that associates with membrane immunoglobulin (mIgM). CD79b expression is exclusive to B lymphocytes. Depending on the maturation state of the B cell, CD79b can be expressed either in the cytoplasm or on the cell surface. The CD79 receptor complex triggers numerous signaling pathways to mediate B cell development, maintenance, and activation.

References: Procedures for the Collection of Diagnostic Blood Specimens by Venipuncture (H3-A6), 3rd Edition published by the National Committee for Clinical Laboratory Standards.

Nakamura T, Kubagawa H, Cooper MD. Heterogeneity of immunoglobulin-associated molecules on human B cells identified by monoclonal antibodies. Proc Natl Acad Sci USA. 1992 Sep 15;89(18):8522-6.

Schlossman S, Bloumsell L, et al, eds. Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York. 1995.