Anti-Human CD74 Purified (See Replacement Product: cat. 14-0747)

Description: The LN2 monoclonal antibody recognizes CD74 (MHC Class II-associated invariant chain), which is a 33-43 kDa nonpolymorphic type II membrane protein. CD74 is expressed on B cells, at lower levels on monocytes and macrophages, and on subsets of activated T cells, Langerhans cells, dendritic cells and epithelial cells. CD74 is known to act as a chaperone of MHC Class II (HLA-DR) proteins, promoting their exit from the ER and directing them to endocytic compartments. However, recently a signaling function has been demonstrated for CD74 based on its interaction with CD44 and its binding of the proinflammatory cytokine macrophage migration-inhibitory factor (MIF). CD74 is also thought to play a role in the maturation of follicular B-cells and accumulation of marginal zone B-cells.

References: Epstein AL, Marder RJ, Winter JN, Fox RI. Two new monoclonal antibodies (LN-1, LN-2) reactive in B5 formalin-fixed, paraffin-embedded tissues with follicular center and mantle zone human B lymphocytes and derived tumors.J Immunol. 1984 Aug;133(2):1028-36. (LN2, IHC (Paraffin), IP, PubMed)

Lamb CA, Yewdell JW, Bennink JR, Cresswell P. Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus.Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):5998-6002.

Becker-Herman S, Arie G, Medvedovsky H, Kerem A, Shachar I. CD74 is a member of the regulated intramembrane proteolysis-processed protein family.Mol Biol Cell. 2005 Nov;16(11):5061-9.