Anti-Human CD71 (Transferrin Receptor) APC

Description: The OKT9 monoclonal antibody reacts with human CD71, a 170-180 kDa type II transmembrane protein. CD71, the transferrin receptor, exists as a homodimer on the cell surface and is essential for cellular growth. CD71 is expressed by immature proliferating cells and at low levels on resting mature lymphocytes. Antigen or mitogen stimulation of T and B cells upregulates the expression of CD71.

References: Wenning LA, Murphy RM. 1999. Coupled cellular trafficking and diffusional limitations in delivery of immunotoxins to multicell tumor spheroids. Biotechnol Bioeng. 62(5):562-75

Terng HJ, Gessner R, Fuchs H, Stahl U, Lang C. Human transferrin receptor is active and plasma membrane-targeted in yeast. FEMS Microbiol Lett. 1998 Mar 1;160(1):61-7 (OKT9, IHC (electron microscopy), PubMed)

Franco A, Paroli M, Testa U, Benvenuto R, Peschle C, Balsano F, Barnaba V. Transferrin receptor mediates uptake and presentation of hepatitis B envelope antigen by T lymphocytes. J Exp Med. 1992 May 1;175(5):1195-205. (OKT9, FA, PubMed)

Salcedo TW, Fleit HB. 1991. Plasma membrane and intracellular pools of transferrin receptors decline during in vitro cultivation of U937 cells. Cell Prolif. 24(4):383-401

Sutherland R, Delia D, Schneider C, Newman R, Kemshead J, Greaves M. 1981. Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin. Proc Natl Acad Sci U S A. 78(7): 4515–4519.