Anti-Human CD62L (L-Selectin) eFluor® 450

Description: The DREG-56 monoclonal antibody reacts with human CD62L, a 76 kDa member of the selectin family. CD62L is expressed by neutrophils, monocytes, and subsets of T, B, and NK cells and binds a number of glycosylated, fucosylated, sulfated sialylated glycoproteins including CD34, glycam-1 and MAdCAM-1. These interactions mediate rolling of lymphocytes on activated endothelium at the sites of inflammation and homing of cells to the high endothelial venules (HEV) of peripheral lymphoid tissues.

References: Jutila MA, Kurk S, Jackiw L, Knibbs RN, Stoolman LM. J Immunol. L-selectin serves as an E-selectin ligand on cultured human T lymphoblasts. 2002 Aug 15;169(4):1768-73. (Dreg-56, WB, PubMed)

Schlossman, S., L. Bloumsell, et al. eds. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York.

Kishimoto TK, Jutila MA, Butcher EC. Identification of a human peripheral lymph node homing receptor: a rapidly down-regulated adhesion molecule. Proc Natl Acad Sci U S A. 1990 Mar;87(6):2244-8. (Dreg-56, mAb generation, WB, FC, PubMed)