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Anti-Human CD62E (E-Selectin) Purified

Also known as: LECAM-2

Clone: P2H3

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 14-0627

Cat. No. Size
14-0627-80 25 ug
14-0627-82 100 ug
Please inquire about custom configurations or bulk packaging.

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Data for Anti-Human CD62E (E-Selectin) Purified.

Staining of TNF alpha-stimulated Human Umbilical Vein Endothelial Cells (HUVEC) with 0.5 ug of Mouse...View More

  • Data for Anti-Human CD62E (E-Selectin) Purified.
Description

Description: The P2H3 monoclonal antibody reacts with human CD62E, a 97-115 kDa member of the selectin family. CD62E, also known as E-selectin or endothelial-leukocyte adhesion molecule-1 (ELAM-1) is an adhesion molecule expressed by endothelial cells upon stimulation with cytokines including TNFα and IL-1β. Induced expression of CD62E during inflammatory conditions is thought to mediate leukocyte rolling including the initial interaction of neutrophils with endothelium.

The P2H3 monoclonal antibody also inhibits cellular adhesion to cytokine-activated endothelial cells.

Details
Host Mouse
Isotype IgG1
Reactivity Human
Conjugate Purified
Reported Applications Flow Cytometric Analysis, Immunohistochemical Staining, Functional Assays, Immunoprecipitation
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
12-0627 Anti-Human CD62E (E-Selectin) PE 488 - 561 nm 575 nm FC RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
14-4714 Mouse IgG1 K Isotype Control Purified FC, ICC, IHC, IP, WB RUO
References

References: Bevilacqua MP, Stengelin S, Gimbrone MA Jr, Seed B.Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins.Science. 1989 Mar 3;243(4895):1160-5.

Graber N, Gopal TV, Wilson D, Beall LD, Polte T, Newman W.T cells bind to cytokine-activated endothelial cells via a novel, inducible sialoglycoprotein and endothelial leukocyte adhesion molecule-1.J Immunol. 1990 Aug 1;145(3):819-30.

Phillips ML, Nudelman E, Gaeta FC, Perez M, Singhal AK, Hakomori S, Paulson JC.ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex.Science. 1990 Nov 23;250(4984):1130-2.

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