CD49d (Integrin alpha 4) APC-eFluor® 780

Description: The 9F10 monoclonal antibody reacts with human CD49d, the 150 kDa integrin alpha 4 subunit. The complex of CD49d non-covalently associated with integrin beta 1(CD29), also known as VLA-4, is a receptor for fibronectin and VCAM-1 (CD106). This complex is expressed by thymocytes, peripheral lymphocytes, monocytes and eosinophils. CD49d also associates with integrin beta 7 and binds to the Mucosal Addressin Cell-Adhesion Molecule-1 (MadCAM-1).

References: Procedures for the Collection of Diagnostic Blood Specimens by Venipuncture (H3-A6), 3rd Edition published by the National Committee for Clinical Laboratory Standards.

Schlossman S, Bloumsell L, et al, eds. Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York. 1995.