Anti-Human CD44var (v7-v8) Purified

Description: Specifically recognizes an epitope encoded by exons v7-v8 on the variant portion of human CD44.

Standard CD44 (CD44s) lacks the entire variable region and is found mainly in cells of lymphohematopoietic origin. The multiple isoforms (designated CD44v; v = variant) contain alternatively spliced exons inserted within the extracellular domain. These isoforms are known as CD44v1, CD44v2, CD44v3, CD44v4, CD44v5, CD44v6, CD44v7, CD44v8, CD44v9, CD44v10, CD44v11.

Citations: Bruno,Silvia; Fabbi,Marina; Tiso,Micaela; Santamaria,Barbara; Ghiotto,Fabio; Saverino,Daniele; Tenca,Claudya; Zarcone,Daniela; Ferrini,Silvano; Ciccone,Ermanno; Grossi,Carlo E.. Cell activation via CD44 occurs in advanced stages of squamous cell carcinogenesis. Carcinogenesis 2000;21:893-900. (Link)

Schuster-Kolbe,J.; Ludwig,H.; Adolf,G.R.; Heider,K.H.. Expression of CD44 isoforms on isolated bone marrow plasma cells and peripheral CD19+ B cells of patients with multiple myeloma and healthy individuals. Leuk.Lymphoma 1999;34:95-103. (Link)

Van Hal,Nicole L.W.; van Dongen,Guus A.M.S.; Ten Brink,Corlinda B.M.; Heider,Karl Heinz; Rech-Weichselbraun,Irene; Snow,Gordon B.; Brakenhoff,Ruud H.. Evaluation of Soluble CD44v6 as a Potential Serum Marker for Head and Neck Squamous Cell Carcinoma. Clinical Cancer Research 1999;5:3534-3541. (Link)

Nishimura,S.; Chung,Y.S.; Yashiro,M.; Inoue,T.; Sowa,M.. CD44H Plays an Important Role in Peritoneal Dissemination of Scirrhous Gastric Cancer Cells. Japanese Journal of Cancer Research 1996;87:1235-1244. (Link)

Sconocchia,G.; Titus,J.A.; Segal,D.M.. CD44 is a cytotoxic triggering molecule in human peripheral blood NK cells. The Journal of Immunology 1994;153:5473-5481. (Link)

CHUANG,C.K.; SHEN,Y.C.; WU,J.H.; TSAI,L.H.; LIAO,S.K.. IMMUNOBIOLOGIC, CYTOGENETIC AND DRUG RESPONSE FEATURES OF A NEWLY ESTABLISHED CELL LINE (SCRC-1) FROM RENAL SMALL CELL... The Journal of urology 2000;163:1016-1021. (Link)

Hart,S.P.; Dougherty,G.J.; Haslett,C.; Dransfield,I.. CD44 regulates phagocytosis of apoptotic neutrophil granulocytes, but not apoptotic lymphocytes, by human macrophages. The Journal of Immunology 1997;159:919-925. (Link)