anti-mouse CD44var (v6)

Description: Specifically recognizes an epitope encoded by exon v6 on the variant portion of murine CD44.

Standard CD44 (CD44s) lacks the entire variable region and is found mainly in cells of lymphohematopoietic origin. The multiple isoforms (designated CD44v; v = variant) contain alternatively spliced exons inserted within the extracellular domain. These isoforms are known as CD44v1, CD44v2, CD44v3, CD44v4, CD44v5, CD44v6, CD44v7, CD44v8, CD44v9, CD44v10, CD44v11.

BMS145 is suitable for ELISA and Western Blot analysis.

Citations: Wang,Xiaoping; Chen,Wei; Li,Xu; Lin,Huanping; Wang,Qiaoxia. Heat shock protein 72 associated with CD44v6 in human colonic adenocarcinoma. Cell Biology International 2008;32:860-864. (Link)

Wittig,Bianca M.; Johansson,Britt; Zoller,Margot; Schwarzler,Christoph; Gunthert,Ursula. Abrogation of Experimental Colitis Correlates with Increased Apoptosis in Mice Deficient for CD44 Variant Exon 7 (CD44v7). Journal of Experimental Medicine 2000;191:2053-2064. (Link)

Larkin,Jonathan; Renukaradhya,Gourapura J.; Sriram,Venkataraman; Du,Wenjun; Gervay-Hague,Jacquelyn; Brutkiewicz,Randy R.. CD44 Differentially Activates Mouse NK T Cells and Conventional T Cells. The Journal of Immunology 2006;177:268-279. (Link)

Recio,Juan A.; Merlino,Glenn. Hepatocyte Growth Factor/Scatter Factor Induces Feedback Up-Regulation of CD44v6 in Melanoma Cells through Egr-1. Cancer Research 2003;63:1576-1582. (Link)

Salaun,B.; de Saint-Vis,B.; Pacheco,N.; Pacheco,Y.; Riesler,A.; Isaac,S.; Leroux,C.; Clair-Moninot,V.; Pin,J.J.; Griffith,J.; Treilleux,I.; Goddard,S.; Davoust,J.; Kleijmeer,M.; Lebecque,S.. CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes. Am J Pathol. 2004;164:861-871. (Link)

Madison,Blair B.; Braunstein,Katherine; Kuizon,Erlene; Portman,Kathleen; Qiao,Xiaotan T.; Gumucio,Deborah L.. Epithelial hedgehog signals pattern the intestinal crypt-villus axis. Development 2005;132:279-289. (Link)