Anti-Human CD44var (v5) Purified

Also known as: VFF-8 Phagocytic glycoprotein I, Hermes antigen

Clone: VFF-8

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# BMS115*

Cat. No. Size
BMS115 100 ug
Please inquire about custom configurations or bulk packaging.

To enable ordering, please select your country. Cookies will need to be enabled to continue on our website. View our Privacy Policy.

Description

Description: Specifically recognizes an epitope encoded by exon v5 on the variant portion of human CD44.

Standard CD44 (CD44s) lacks the entire variable region and is found mainly in cells of lymphohematopoietic origin. The multiple isoforms (designated CD44v; v = variant) contain alternatively spliced exons inserted within the extracellular domain. These isoforms are known as CD44v1, CD44v2, CD44v3, CD44v4, CD44v5, CD44v6, CD44v7, CD44v8, CD44v9, CD44v10, CD44v11.

Details
Host Mouse
Isotype lgG1
Reactivity Human
Conjugate Purified
Reported Applications Flow Cytometric Analysis, Immunohistochemical Staining, Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections, Western Blotting
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
BMS115BT* Anti-Human CD44var (v5) Biotin FC RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
BMS114* Anti-Human CD44var (v4) Purified FC, IHC RUO
BMS118* Anti-Human CD44var (v7-v8) Purified FC, IHC, WB RUO
BMS119* anti-human CD44var (v10) WB RUO
BMS124* anti-human CD44var (v3-v10) IHC, WB RUO
BMS144* Anti-Human CD44var (v3) Purified FC, IHC, WB RUO
References

Citations: Bruno,Silvia; Fabbi,Marina; Tiso,Micaela; Santamaria,Barbara; Ghiotto,Fabio; Saverino,Daniele; Tenca,Claudya; Zarcone,Daniela; Ferrini,Silvano; Ciccone,Ermanno; Grossi,Carlo E.. Cell activation via CD44 occurs in advanced stages of squamous cell carcinogenesis. Carcinogenesis 2000;21:893-900. (Link)

Van Hal,Nicole L.W.; van Dongen,Guus A.M.S.; Ten Brink,Corlinda B.M.; Heider,Karl Heinz; Rech-Weichselbraun,Irene; Snow,Gordon B.; Brakenhoff,Ruud H.. Evaluation of Soluble CD44v6 as a Potential Serum Marker for Head and Neck Squamous Cell Carcinoma. Clinical Cancer Research 1999;5:3534-3541. (Link)

Franzmann,Elizabeth J.; Reategui,Erika P.; Carraway,Kermit L.; Hamilton,Kara L.; Weed,Donald T.; Goodwin,W.Jarrard. Salivary Soluble CD44: A Potential Molecular Marker for Head and Neck Cancer. Cancer Epidemiology Biomarkers & Prevention 2005;14:735-739. (Link)

Scott,David A.; Stapleton,John A.; Palmer,Richard M.; Wilson,Ron F.; Sutherland,Gay; Coward,Paula Y.; Gustavsson,Gunnar; Odell,Edward W.; Poston,Robin N.. Plasma Concentrations of Reputed Tumor-associated Soluble CD44 Isoforms (v5 and v6) in Smokers Are Dose Related and Decline on Smoking Cessation. Cancer Epidemiology Biomarkers & Prevention 2000;9:1211-1214. (Link)

Sconocchia,G.; Titus,J.A.; Segal,D.M.. CD44 is a cytotoxic triggering molecule in human peripheral blood NK cells. The Journal of Immunology 1994;153:5473-5481. (Link)

Tibesku,C.O.; Szuwart,T.; Ocken,S.A.; Skwara,A.; Fuchs,S.. Expression of the matrix receptor CD44v5 on chondrocytes changes with osteoarthritis: an experimental investigation in the rabbit. Annals of the Rheumatic Diseases 2006;65:105-108. (Link)

CHUANG,C.K.; SHEN,Y.C.; WU,J.H.; TSAI,L.H.; LIAO,S.K.. IMMUNOBIOLOGIC, CYTOGENETIC AND DRUG RESPONSE FEATURES OF A NEWLY ESTABLISHED CELL LINE (SCRC-1) FROM RENAL SMALL CELL... The Journal of urology 2000;163:1016-1021. (Link)

Lee,Shih Chun; Harn,Horng Jyh; Lin,Torng Sen; Yeh,Kun Tu; Liu,Yao Chi; Tsai,Chien Sung; Cheng,Yeung Leung. Prognostic significance of CD44v5 expression in human thymic epithelial neoplasms. Annals of Thoracic Surgery 2003;76:213-218. (Link)

Leth-Larsen,Rikke; Lund,Rikke; Hansen,Helle V.; Laenkholm,Anne Vibeke; Tarin,David; Jensen,Ole N.; Ditzel,Henrik J.. Metastasis-related plasma membrane proteins of human breast cancer cells identified by comparative quantitative mass spectrometry. Molecular and Cellular Proteomics 2009;M800061-MMCP200. (Link)

Bankfalvi; Terpe,H.J.; Breukelmann,D.; Bier,B.; Rempe,D.; Pschadka,G.; Krech,R.; Bocker,W.. Gains and losses of CD44 expression during breast carcinogenesis and tumour progression. Histopathology 1998;33:107-116. (Link)

Sarli,Giuseppe; Sassi,Francesco; Brunetti,Barbara; Rizzo,Antonio; Diracca,Laura; Benazzi,Cinzia. Lymphatic vessels assessment in feline mammary tumours. BMC Cancer 2007;7:7-7. (Link)

Berner,H.S.; Suo,Z.; Risberg,B.; Villman,K.; Karlsson,M.G.; Nesland,J.M.. Clinicopathological associations of CD44 mRNA and protein expression in primary breast carcinomas. Histopathology 2003;42:546-554. (Link)