anti-human CD44var (v10)

Also known as: VFF-14 Phagocytic glycoprotein I, Hermes antigen

Clone: VFF-14

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# BMS119*

Cat. No. Size
BMS119 100 ug
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Description

Description: Specifically recognizes an epitope encoded by exon v10 on the variant portion of human CD44.

Standard CD44 (CD44s) lacks the entire variable region and is found mainly in cells of lymphohematopoietic origin. The multiple isoforms (designated CD44v; v = variant) contain alternatively spliced exons inserted within the extracellular domain. These isoforms are known as CD44v1, CD44v2, CD44v3, CD44v4, CD44v5, CD44v6, CD44v7, CD44v8, CD44v9, CD44v10, CD44v11.

Details
Host Mouse
Isotype IgG1
Reactivity Human
Conjugate Purified
Reported Applications Western Blotting
Documentation
TDS Link Download TDS
Related Products
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BMS114* Anti-Human CD44var (v4) Purified FC, IHC RUO
BMS115* Anti-Human CD44var (v5) Purified FC, IHC, WB RUO
BMS116* Anti-Human CD44var (v6) Purified FC, IHC, WB RUO
BMS117* Anti-Human CD44var (v7) Purified FC, IHC, WB RUO
BMS118* Anti-Human CD44var (v7-v8) Purified FC, IHC, WB RUO
References

Citations: Schuster-Kolbe,J.; Ludwig,H.; Adolf,G.R.; Heider,K.H.. Expression of CD44 isoforms on isolated bone marrow plasma cells and peripheral CD19+ B cells of patients with multiple myeloma and healthy individuals. Leuk.Lymphoma 1999;34:95-103. (Link)

Saegusa,Makoto; Okayasu,Isao. Up-regulation of CD44 Variant Exon Expression in Endometrial Carcinomas: Analysis of mRNA and Protein Isoforms, and Relation to Clinicopathological Factors. Cancer Science 1998;89:291-298. (Link)

Van Hal,Nicole L.W.; van Dongen,Guus A.M.S.; Ten Brink,Corlinda B.M.; Heider,Karl Heinz; Rech-Weichselbraun,Irene; Snow,Gordon B.; Brakenhoff,Ruud H.. Evaluation of Soluble CD44v6 as a Potential Serum Marker for Head and Neck Squamous Cell Carcinoma. Clinical Cancer Research 1999;5:3534-3541. (Link)

Sconocchia,G.; Titus,J.A.; Segal,D.M.. CD44 is a cytotoxic triggering molecule in human peripheral blood NK cells. The Journal of Immunology 1994;153:5473-5481. (Link)

Hoffmann,U.; Heilmann,K.; Hayford,C.; Stallmach,A.; Wahnschaffe,U.; Zeitz,M.; Gunthert,U.; Wittig,B.. CD44v7 ligation downregulates the inflammatory immune response in Crohn's disease patients by apoptosis induction in mononuclear cells from the lamina propria. Cell Death Differ 2007;(Link)

CHUANG,C.K.; SHEN,Y.C.; WU,J.H.; TSAI,L.H.; LIAO,S.K.. IMMUNOBIOLOGIC, CYTOGENETIC AND DRUG RESPONSE FEATURES OF A NEWLY ESTABLISHED CELL LINE (SCRC-1) FROM RENAL SMALL CELL... The Journal of urology 2000;163:1016-1021. (Link)

Rodriguez-Rodriguez,L.; Sancho-Torres,I.; Gibbon,D.G.; Miller Watelet,L.F.; Mesonero,C.. CD44-9v and CD44-10v are potential molecular markers for squamous cell carcinoma of the vulva. Journal of the Society for Gynecologic Investigation 2000;7:70-75. (Link)

Stauder,R.; Van Driel,M.; Schwarzler,C.; Thaler,J.; Lokhorst,H.M.; Kreuser,E.D.; Bloem,A.C.; Gunthert,U.; Eisterer,W.. Different CD44 splicing patterns define prognostic subgroups in multiple myeloma. Blood 1996;88:3101-3108. (Link)