eZFluor™ Anti-Human CD4 FITC and CD8 PE Cocktail

Description: This product consists of two fluorochrome-conjugated monoclonal antibodies to distinguish human peripheral CD4⁺ and CD8⁺ T cells. The RPA-T4 monoclonal antibody (mouse IgG1, κ) reacts with human CD4, a 59 kDa cell surface receptor expressed by a majority of thymocytes, subpopulation of mature T cells (T helper cells) and in low levels on monocytes. CD4 is a receptor for the human immunodeficiency virus (HIV). The RPA-T8 monoclonal antibody (mouse IgG1, κ) reacts with the human CD8a molecule, an approximately 32-34 kDa cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8αβ) or as a homodimer (CD8αα). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells.

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Schlossman, S., L. Bloumsell, et al. eds. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York.

Knapp, W., B. Dorken, et al. eds. 1989. Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press. New York.