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Anti-Human CD39 PE

Also known as: Ectonucleoside Triphosphate Diphosphohydrolase 1, Entpd1

Clone: eBioA1 (A1)

RUO: For Research Use Only. Not for use in diagnostic procedures.

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SKU# 12-0399

Cat. No. Size
12-0399-41 25 tests
12-0399-42 100 tests

Data for Anti-Human CD39 PE.

Staining of normal human peripheral blood cells with Anti-Human CD39 PE, followed by fixation and...View More

  • Data for Anti-Human CD39 PE.
Description

Description: The eBioA1 monoclonal antibody reacts with human CD39 also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) or NTPDase. CD39 is an integral membrane protein with two transmembrane domains and exists as a homotetramer. It is the most prominent ectoenzyme of the immune system. The function of CD39 is to effectively remove toxic extracellular ATP by converting it to ADP or AMP. CD39 is thought to work together with CD73 to hydrolyze ATP and has been well characterized on Langerhans cells. Expression of CD39 was originally identified on activated lymphocytes. Expression is also found on a subset of T cells, B cells and dendritic cells as well as weak staining on monocytes and granulocytes.

Recently, CD39 and CD73 have been found on regulatory T cells (Treg). Expression of CD39 on Treg may facilitate their entry into inflamed areas where high levels of ATP are present. Expression of CD39 on Foxp3+CD4+ cells ranges from 25-45%.

Details
Host Mouse
Isotype IgG1, kappa
Reactivity Human
Conjugate PE
Laser Blue Laser, Green Laser, Yellow-Green Laser
Emit 578 nm
Excite 488 - 561 nm
Reported Applications Flow Cytometric Analysis
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
17-0399 Anti-Human CD39 APC 633 - 647 nm 660 nm FC RUO
46-0399 Anti-Human CD39 PerCP-eFluor® 710 488 nm 710 nm FC RUO
14-0399 Anti-Human CD39 Purified FC, IHC, IHC-F RUO
25-0399 Anti-Human CD39 PE-Cyanine7 488 - 561 nm 775 nm FC RUO
11-0399 Anti-Human CD39 FITC 488 nm 520 nm FC RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
00-5523 Foxp3 / Transcription Factor Staining Buffer Set FC GPR
17-4776 Anti-Human Foxp3 APC 633 - 647 nm 660 nm FC RUO
12-4714 Mouse IgG1 K Isotype Control PE 488 - 561 nm 578 nm FC RUO
References

References: Lyck L, Dalmau I, et al. 2008. Immunohistochemical markers for quantitative studies of neurons and glia in human neocortex. J Histochem Cytochem. 56(3):201-21. (A1, IHC frozen, PubMed)

Borsellino G, Kleinewietfeld M, Di Mitri D, Sternjak A, Diamantini A, Giometto R, Hopner S, Centonze D, Bernardi G, Dell'acqua ML, Rossini PM, Battistini L, Rotzschke O, Falk K. 2007. Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood. 110(4):1225-32.

Stockl J., O. Majdic, G. Fischer, D. Maurer, W. Knapp. 2001. Monomorphic Molecules Function as Additional Recognition Structures on Haptenated Target Cells for HLA-A1-Restricted, Hapten-Specific CTL. J. Immunol. 167L:2724-2733

Aversa GG., J.A. Waugh, G.A. Bishop, B.M. Hall. 1989. Use of Monoclonal Antibodies to Study in vivo and in vitro-activated Lymphocytes. Transplant Proc. 21(1):349-50.

Aversa GG., M.G. Suranyi, J.A. Waugh, A.G. Bishop, B.M. Hall. 1988. Detection of a Late Lymphocyte Activation Marker by A1, a New Monoclonal Antibody. Transplant Proc. 20(1):49-52.


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