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Anti-Human CD355 (CRTAM) PE-Cyanine7

Also known as: Cytotoxic and regulatory T cell molecule, Class-I MHC-restricted T-cell-associated molecule

Clone: Cr24.1

RUO: For Research Use Only. Not for use in diagnostic procedures.

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SKU# 25-3559

Cat. No. Size
25-3559-41 25 tests
25-3559-42 100 tests

Data for Anti-Human CD355 (CRTAM) PE-Cyanine7.

Staining of unstimulated (left) or Cell Stimulation Cocktail (cat. 00-4970)-stimulated (right)...View More

  • Data for Anti-Human CD355 (CRTAM) PE-Cyanine7.
  • Data for Anti-Human CD355 (CRTAM) PE-Cyanine7.
Description

Description: This monoclonal antibody Cr24.1 reacts with human CD355, also known as Class-I MHC-restricted T-cell-associated molecule (CRTAM). CD355 usually exists as a homodimer, however, it forms a heterodimer with its ligand Necl-2. CD355 is transiently expressed by activated NK, NKT, gamma delta T, and CD8+ T cells. CD355 is also expressed by Purkinje neurons. Human CD355 is involved in immunosurveillance of cancer cells, gamma delta T cell survival, cell polarity, retention of lymphocytes in lymph nodes, promotion of cytotoxicity in NK cells, and IFN gamma secretion from CD8+ T cells.

Cr24.1 has been reported to have antagonist activity.

Details
Host Mouse
Isotype IgG2a, kappa
Reactivity Human
Conjugate PE-Cyanine7
Laser Blue Laser, Green Laser, Yellow-Green Laser
Emit 775 nm
Excite 488 - 561 nm
Reported Applications Flow Cytometric Analysis
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
17-3559 Anti-Human CD355 (CRTAM) APC 633 - 647 nm 660 nm FC RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
00-4970 Cell Stimulation Cocktail (500X) FC, ELISA, FA GPR
25-4724 Mouse IgG2a K Isotype Control PE-Cyanine7 488 - 561 nm 775 nm FC RUO
11-0088 Anti-Human CD8a FITC 488 nm 520 nm FC RUO
References

References: Zhang S, Lu G, Qi J, Li Y, Zhang Z, Zhang B, Fan Z, Yan J, Gao GF. Competition of cell adhesion and immune recognition: insights into the interaction between CRTAM and nectin-like 2. Structure. 2013 Aug 6;21(8):1430-9.

Dessarthe B, Thedrez A, Latouche JB, Cabillic F, Drouet A, Daniel P, de La Pintiere CT, Catros V, Toutirais O. CRTAM receptor engagement by Necl-2 on tumor cells triggers cell death of activated Vg9Vd2 T cells. J Immunol. 2013 May 1;190(9):4868-76.

Patino-Lopez G, Hevezi P, Lee J, Willhite D, Verge GM, Lechner SM, Ortiz-Navarrete V, Zlotnik A. Human class-I restricted T cell associated molecule is highly expressed in the cerebellum and is a marker for activated NKT and CD8+ T lymphocytes. J Neuroimmunol. 2006 Feb;171(1-2):145-55.

Boles KS, Barchet W, Diacovo T, Cella M, Colonna M. The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. Blood. 2005 Aug 1;106(3):779-86. (Cr24.1 FC PubMed)


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