CD34 PE-Cy7

Clone: 4H11 (APG)

Analyte Specific Reagent (ASR): Analytical and performance characteristics are not established.

SKU# 8025-0349

Cat. No.	Size
8025-0349-025	25 tests
8025-0349-120	120 tests
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Fluorescence profiles of normal human peripheral blood cells showing autofluorescence of unstained...View More

Description

Description: The 4H11 monoclonal antibody reacts with human CD34, also known as mucosialin. CD34 belongs to a protein family which also includes endoglycan and podocalyxin. Members of this family are single pass transmembrane proteins with a heavily glycosylated extracellular and N-terminal mucin domain. CD34 was first identified as an antigen expressed on hematopoietic progenitors, and has since been extensively used as a marker to isolate cells capable of hematopoietic cell engraftment. In spite of this, the function of CD34 remains unresolved. In addition to expression on hematopoietic progenitors, CD34 is expressed on some populations of mesenchymal stem cells, tumor cell lines, and by vascular endothelia in the adult. Epitopes of CD34 have been assigned to three classes (class I, II or III) based on their differential sensitivity to enzymatic cleavage by neuraminidase, chymopapain, or O-glycoprotease. According to this analysis, the 4H11 antibody belongs to class III, indicating that it reacts with a protein epitope.

Details

Host	Mouse
Isotype	IgG1, kappa
Reactivity	Human
Conjugate	PE-Cyanine7
Laser	Blue Laser
Emit	760 nm
Excite	488 nm
Legal	For research (not to include in vivo research) and/or in vitro diagnostic use only. The only permitted commercial use is provision of research (not to include in vivo research) services and/or in vitro diagnostic services. Not for therapeutic or in vivo applications. Other use needs licenses which are available from GE Healthcare Bio-Sciences Corp. Under U.S. patent nos. Nos 5,268,486, 5,569,587 and 5,627,027 and foreign equivalents and pending applications. This product is subject to proprietary rights of GE Healthcare Bio-Sciences Corp. (“GE Healthcare”) and Carnegie Mellon University (“CMU”) and made and sold under license from GE Healthcare. The product bearing this label is licensed for sale only for research (not to include in vivo research) and in addition may be used to perform research (not to include in vivo research) and/or in vitro diagnostic services for third parties. It is not licensed nor are there any implied licenses for any other use including, without limitation, commercial uses unless expressly authorized by GE Healthcare in writing. If you intend to use this product commercially and you do not have a license to use this product for the intended commercial purpose, return this product, unopened to eBioscience, Inc. 10255 Science Center Drive, San Diego, California 92121 USA and any money paid for the product will be refunded.
Reported Applications	Flow Cytometric Analysis

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
8017-0349	CD34 APC	633 - 647 nm	660 nm		ASR
8043-0349	CD34 PerCP	488 nm		FC	ASR
8012-0349	CD34 PE	488 nm	575 nm		ASR
8011-0349	CD34 FITC	488 nm	518 nm	FC	ASR
8046-0349	CD34 PerCP-eFluor® 710	488 nm	710 nm		ASR

References

References: Sutherland DR, Watt SM, Dowden G, Karhi K, Baker MA, Greaves MF, Smart JE. Structural and partial amino acid sequence analysis of the human hemopoietic progenitor cell antigen CD34.Leukemia. 1988 Dec;2(12):793-803.

Baumheter S, Singer MS, Henzel W, Hemmerich S, Renz M, Rosen SD, Lasky LA. Binding of L-selectin to the vascular sialomucin CD34.Science. 1993 Oct 15;262(5132):436-8.

View More Products

Antigens	Area of Biology	Cell Type	Formats
CD34	Stem Cell Biology Adhesion & Migration Innate Immunity Angiogenesis	Dendritic Cells Hematopoietic Stem Cells	PE-Cyanine7