Anti-Human CD32 Functional Grade Purified

Description: This 6C4 monoclonal antibody reacts with human CD32 (also known as FcγRII). This antibody recognizes two isoforms of the receptor, FcγRIIA and FcγRIIB. These 40-kDa polymorphic transmembrane glycoproteins are expressed on B cells, granulocytes, monocytes, macrophages, and platelets. Moreover, these receptors are detected on natural killer cells. CD32 enables interaction between FcγRII-expressing cells and opsonized antigen or IgG-containing immune complexes. Both receptors exhibit low affinity towards IgG and play a role in inflammation and autoimmune disease. This clone has been reported to inhibit Ig binding in a rosette blocking assay.

References: Fossati G, Bucknall RC, and Edwards SW. Fcgamma receptors in autoimmune diseases. Eur. J. Clin. Invest. 2001 31(9):821-831.

Vely F, Gruel N, Moncuit J, Cochet O, Rouard H, Dare S, Galon J, Sautes C, Fridman WH, Teillaud JL. A new set of monoclonal antibodies against human Fc gamma RII (CD32) and Fc gamma RIII (CD16): characterization and use in various assays. Hybridoma 1997 Dec; 16(6):519-28. (6C4, FC, FA (blocking), Pubmed)