Anti-Human CD314 (NKG2D) Purified

Description: The 5C6 monoclonal antibody reacts with the human NKG2D, a 42 kDa lectin-like molecule expressed by NK cells, γδ T cells, some CD4⁺ and CD8⁺ T cells. Human NKG2D forms complexes with DAP10, a membrane adaptor protein, and has the ability to costimulate multiple NK activation receptors. The counter-receptor for human NKG2D has been identified as MICA/MICB expressed on epithelial tumors from lung, breast, kidney, ovary, prostate and colon carcinoma. 5C6 and 1D11 block binding of soluble MICA to γδ TCR T cell clones and inhibit lysis by these cells. 5C6 and 1D11 induced NKG2D function of redirected lysis of FcReceptor bearing P815 cells.

References:
Veronika Groh, Alexander Steinle, Stefan Bauer, and Thomas Spies. 1998. Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial T Cells. Science. 279:1737-1740.

Stefan Bauer, Veronika Groh, Jun Wu, Alexander Steinle, Joseph H. Phillips, Lewis L. Lanier, and Thomas Spies. 1999. Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA. Science. 285: 727-729.

Seiler M, Brabcova I, Viklicky O, Hribova P, Rosenberger C, Pratschke J, Lodererova A, Matz M, Schönemann C, Reinke P, Volk HD, Kotsch K. Heightened expression of the cytotoxicity receptor NKG2D correlates with acute and chronic nephropathy after kidney transplantation. Am J Transplant. 2007 Feb;7(2). (5c6, IH/F, PubMed)