Anti-Human CD314 (NKG2D) PE

Description: The 1D11 monoclonal antibody reacts with the human NKG2D, a 42 kDa lectin-like molecule expressed by NK cells, gamma delta T cells, some CD4+ and CD8+ T cells. Human NKG2D forms complexes with DAP10, a membrane adaptor protein, and has the ability to costimulate multiple NK activation receptors. The counter-receptor for human NKG2D has been identified as MICA/MICB expressed on epithelial tumors from lung, breast, kidney, ovary, prostate and colon carcinoma. 5C6 and 1D11 block binding of soluble MICA to gamma delta TCR T cell clones and inhibit lysis by these cells. 5C6 and 1D11 induced NKG2D function of redirected lysis of FcReceptor bearing P815 cells.

References: Groh V, Bruhl A, El-Gabalawy H, Nelson JL, Spies T. Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2003. 100(16):9452-7, (IHC frozen, PubMed)

Roberts AI, Lee L, Schwarz E, Groh V, Spies T, Ebert EC, Jabri B. NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment. J Immunol. 2001. 167(10):5527-30. (activation, PubMed)

Stefan Bauer, Veronika Groh, Jun Wu, Alexander Steinle, Joseph H. Phillips, Lewis L. Lanier, and Thomas Spies. Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA. Science. 1999. 285: 727-729.

Veronika Groh, Alexander Steinle, Stefan Bauer, and Thomas Spies. Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial T Cells. Science. 1998. 279:1737-1740.