Anti-Human CD314 (NKG2D) PE

Also known as: KLRK1

Clone: 1D11

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 12-5878

Cat. No. Size
12-5878-41 25 tests
12-5878-42 100 tests
Please inquire about custom configurations or bulk packaging.

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Data for Anti-Human CD314 (NKG2D) PE.

Staining of normal human peripheral blood cells with Anti-Human CD8a FITC (cat. 11-0089) and Mouse...View More

  • Data for Anti-Human CD314 (NKG2D) PE.
Description

Description: The 1D11 monoclonal antibody reacts with the human NKG2D, a 42 kDa lectin-like molecule expressed by NK cells, γδ T cells, some CD4+ and CD8+ T cells. Human NKG2D forms complexes with DAP10, a membrane adaptor protein, and has the ability to costimulate multiple NK activation receptors. The counter-receptor for human NKG2D has been identified as MICA/MICB expressed on epithelial tumors from lung, breast, kidney, ovary, prostate and colon carcinoma. 5C6 and 1D11 block binding of soluble MICA to γδ TCR T cell clones and inhibit lysis by these cells. 5C6 and 1D11 induced NKG2D function of redirected lysis of FcReceptor bearing P815 cells.

Details
Host Mouse
Isotype IgG1
Reactivity Human
Conjugate PE
Laser Blue Laser, Green Laser, Yellow-Green Laser
Emit 575 nm
Excite 488 - 561 nm
Reported Applications Flow Cytometric Analysis
Documentation

For complete product information, please download the TDS or IFU document.

TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
16-5878 Anti-Human CD314 (NKG2D) Functional Grade Purified FC, FA RUO
13-5878 Anti-Human CD314 (NKG2D) Biotin FC RUO
17-5878 Anti-Human CD314 (NKG2D) APC 633 - 647 nm 660 nm FC RUO
14-5878 Anti-Human CD314 (NKG2D) Purified FC, IHC, FA, IP RUO
11-5878 Anti-Human CD314 (NKG2D) FITC 488 nm 518 nm FC RUO
References

References:
Veronika Groh, Alexander Steinle, Stefan Bauer, and Thomas Spies. 1998. Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial T Cells. Science. 279:1737-1740.

Stefan Bauer, Veronika Groh, Jun Wu, Alexander Steinle, Joseph H. Phillips, Lewis L. Lanier, and Thomas Spies. 1999. Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA. Science. 285: 727-729.

Groh V, Bruhl A, et al. 2003. Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc Natl Acad Sci U S A. 100(16):9452-7, (IHC frozen, PubMed)

Roberts AI, Lee L, et al. 2001. NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment. J Immunol. 167(10):5527-30. (activation, PubMed)


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