Anti-Human CD300c eFluor® 660 (Alexa® 647 Replacement)

Description: This TX45 monoclonal antibody reacts with human CD300c (also known as LIR). CD300c belongs to the myeloid-associated immunoglobulin-like receptor (MAIR) family of genes located on human chromosome 17, a syntenic region of mouse chromosome 11. This 25-kDa type I membrane protein has a single extracellular Ig-like domain and a short cytoplasmic domain. CD300c is expressed on subsets of T and B cells, NK cells, granulocytes, dendritic cells, mast cells, monocytes, and peritoneal macrophages, where CD300c mediates proinflammatory cytokine production. This molecule has also been linked to the regulation of TNF alpha and IFN alpha secretion in activated plasmacytoid dendritic cells. CD300c associates with the adapter protein DAP12, as well as the Fc gamma.

References: Ju X, Zenke M, Hart DN, Clark GJ. CD300a/c regulate type I interferon and TNF-alpha secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands. Blood. 2008 Aug 15;112(4):1184-94.

Nakahashi C, Tahara-Hanaoka S, Totsuka N, Okoshi Y, Takai T, Ohkohchi N, Honda S, Shibuya K, Shibuya A. Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adapters DAP12 and FcRgamma chain on peritoneal macrophages. J Immunol. 2007 Jan 15;178(2):765-70.

Yotsumoto K, Okoshi Y, Shibuya K, Yamazaki S, Tahara-Hanaoka S, Honda S, Osawa M, Kuroiwa A, Matsuda Y, Tenen DG, Iwama A, Nakauchi H, Shibuya A. Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation. J Exp Med. 2003 Jul 21;198(2):223-33