Anti-Human CD30 Purified

Description: The Ber-H2 monoclonal antibody reacts with human CD30, a 120 kDa transmembrane glycoprotein of the TNFR superfamily. CD30 is expressed on normal activated cells, T and B lymphocytes but not resting lymphocytes. Expression is also found on some lymphomas and embryonal carcinomas as well as HIV, HTLV and EBV infected lymphocytes. Interaction with its ligand, CD30L, leads to signaling and activation of NKκB and subsequently regulates apoptosis.

References: Tamiolakis D, Papadopoulos N, Lambropoulou M, Venizelos J, Verettas D, Tsikouras P, Koutsougeras G, Papadopoulos H, Karpouzis A, Kouskoukis C. Ber-H2 (CD30) Immunohistochemical Staining of Human Fetal Tissues. Int J Biol Sci 2005; 1:135-140.

Polski JM, Janney CG. Ber-H2 (CD30) immunohistochemical staining in malignant melanoma. Mod Pathol. 1999 Sep;12(9):903-6.(Ber-H2, FFPE, PubMed)

Horie R, Watanabe, T. CD30: expression and function in health and disease. J Immunol 1998; 10:457-470.