CD3 eFluor® 450

Description: The SK7 monoclonal antibody reacts with human CD3 epsilon, a 20 kDa subunit of the TCR complex. Along with the other CD3 subunits gamma and delta, the epsilon chain is required for proper assembly, trafficking and surface expression of the TCR complex. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells.

References: Haynes BF. Summary of T-cell studies performed during the Second International Workshop andConference on Human Leukocyte Differentiation Antigens. In: Reinherz EL, Haynes BF, Nadler LM,Bernstein ID, eds. Leukocyte Typing II: Human T Lymphocytes. New York, NY: Springer-Verlag;1986;1:3-30.

Knowles RW. Immunochemical analysis of the T-cell specific antigens. In: Reinherz EL, Haynes BF,Nadler LM, Bernstein ID, eds. Leukocyte Typing II: Human T Lymphocytes. New York, NY:Springer-Verlag; 1986;1:259-288.