Anti-Human CD29 PE

Description: The TS2/16 monoclonal antibody reacts with human CD29, also known as integrin β1, an approximately 130 kDa single-pass transmembrane glycoprotein. CD29 complexes with one of nine integrin α subunits to form the very late antigen (VLA) subfamily of adhesion molecules. Integrin heterodimers containing CD29 are involved in cell-cell and cell-matrix adhesion. CD29 is expressed broadly on lymphocytes and monocytes, with lower levels of expression on granulocytes. The TS2/16 antibody has been found to possess activating activity for β1 integrins.

References: Weber C, Alon R, Moser B, Springer TA. Sequential regulation of alpha4beta1 and alpha5beta1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxis. J Cell Biol. 1996 Aug;134(4):1063-73. (TS2/16, FA, PubMed)

Hemler ME, Sanchez-Madrid F, Flotte TJ, Krensky AM, Burakoff SJ, Bhan AK, Springer TA, Strominger JL. Glycoproteins of 210,000 and 130,000 M.W. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines. J Immunol. 1984 Jun;132(6):3011-8. (TS2/16, IP, IHC, PubMed)

Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA. Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. Proc Natl Acad Sci U S A. 1982 Dec;79(23):7489-93. (TS2/16, IP, FA, PubMed)