Anti-Human CD28 Functional Grade Purified

Also known as: T44

Clone: CD28.6

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 16-0288

Cat. No. Size
16-0288-81 50 ug
16-0288-85 500 ug

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Data for Anti-Human CD28 Functional Grade Purified.

Description

Description: The CD28.6 monoclonal antibody reacts with the human CD28 molecule, a 44 kDa homodimer expressed by thymocytes, mature T cells and plasma cells. CD28 is a ligand for CD80 (B7-1) and CD86 (B7-2) and is a potent costimulator of T cells. Signaling through CD28 augments IL-2 and IL-2 receptor expression as well as cytotoxicity of CD3-activated T cells. The CD28.6 antibody has been reported for use in immunoblotting (WB) and neutralization studies and costimulation in the production of IL-2.

Details
Host Mouse
Isotype IgG2a, kappa
Reactivity Human
Conjugate Functional Grade Purified
Reported Applications Flow Cytometric Analysis, Functional Assays, Western Blotting
Documentation

For complete product information, please download the TDS or IFU document.

TDS Link Download TDS
Additional Formats
References

References: Yang JH, Zhang J, Cai Q, Zhao DB, Wang J, Guo PE, Liu L, Han XH, Shen Q. Expression and function of inducible costimulator on peripheral blood T cells in patients with systemic lupus erythematosus. Rheumatology (Oxford). 2005 Oct;44(10):1245-54. (CD28.6, stimulatory FA, PubMed)

Zhang XG, Olive D, Devos J, Rebouissou C, Ghiotto-Ragueneau M, Ferlin M, Klein B. Malignant plasma cell lines express a functional CD28 molecule. Leukemia. 1998 Apr;12(4):610-8 (CD28.6, blocking FA, PubMed)

Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York.

Kariv I, Truneh A, Sweet RW. Analysis of the site of interaction of CD28 with its counter-receptors CD80 and CD86 and correlation with function. J Immunol. 1996 Jul 1;157(1):29-38 (CD28.6, blocking FA, PubMed)

Bryan RG, Li Y, Lai JH, Van M, Rice NR, Rich RR, Tan TH. Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells. Mol Cell Biol. 1994 Dec;14(12):7933-42. (CD28.6, stimulatory, PubMed)

Nunes J, Klasen S, Ragueneau M, Pavon C, Couez D, Mawas C, Bagnasco M, Olive D. CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events.Int Immunol. 1993 Mar;5(3):311-5.


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