Anti-Human CD28 Functional Grade Purified

Description: The CD28.2 monoclonal antibody reacts with the human CD28 molecule, a 44 kDa homodimer expressed by thymocytes, mature T cells and plasma cells. CD28 is a ligand for CD80 (B7-1) and CD86 (B7-2) and is a potent co-stimulator of T cells. Signaling through CD28 augments IL-2 and IL-2 receptor expression as well as cytotoxicity of CD3-activated T cells.

References: Karlsson I, Malleret B, Brochard P, Delache B, Calvo J, Le Grand R, Vaslin B. FoxP3+ CD25+ CD8+ T-cell induction during primary simian immunodeficiency virus infection in cynomolgus macaques correlates with low CD4+ T-cell activation and high viral load. J Virol. 2007 Dec;81(24):13444-55 (CD28.1, NHP crossreactivity)

Battifora M, Pesce G, Paolieri F, Fiorino N, Giordano C, Riccio AM, Torre G, Olive D, Bagnasco M. B7.1 costimulatory molecule is expressed on thyroid follicular cells in Hashimoto's thyroiditis, but not in Graves' disease. J Clin Endocrinol Metab. 1998 Nov;83(11):4130-9. (CD28.1, IHC frozen)

Nunès J, Klasen S, Ragueneau M, Pavon C, Couez D, Mawas C, Bagnasco M, Olive D. CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events. Int Immunol. 1993 Mar;5(3):311-5.

Schlossman, S., L. Bloumsell, et al eds. 1995.Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York.