Anti-Human CD277 Purified

Description: The eBioBT3.1 monoclonal antibody recognizes BT3.1, BT3.2 and BT3.3. The BT family of proteins is a subgroup of the Ig superfamily (IgSF). BT is a glycoprotein that forms a major component of the milk fat globule molecule. In addition to BT, there are six other genes that have been discovered which have been sub-divided into the BT2 (BT2.1, BT2.2, and BT2.3) and BT3 (BT3.1, BT3.2, and BT3.3) families. BT3.1, BT3.2, and BT3.3 share 95% mRNA identity. BT3 molecules are constitutively expressed on the cell surface of antigen-presenting cells, and the IgV-like domain of BT3.1 is sufficient for interaction with its counter-receptor. BT3.1 is expressed by T cells, B cells and CD14+ cells.

References: Compte, E., P. Pontarotti, Y. Collette, M. Lopez, and D. Olive. 2004. Characterization of BT3 molecules belonging to the B7 family expressed on immune cells. Eur. J. Immunol. 34: 2089-2099. (BT3.1, FC, WB, PubMed)

Tazi-Ahnini, R., J. Henry, C. Offer, C. Bouissou-Bouchouata, I.H. Mather, and P. Pontarotti. 1997. Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex. Immunogenetics. 47: 55-63.