Anti-Human CD268 (BAFF Receptor) Purified

Description: The 8A7 monoclonal antibody reacts with the human BAFF receptor, also known as B lymphocyte stimulator (BLyS protein) receptor, which is expressed on B cells. The ligand for this receptor, BAFF (B cell-activating factor of the TNF family) is a B cell survival factor and regulates CD21/35 and CD23 expression. Interaction of this ligand with its receptor causes elevated CD21/35 and CD23 expression, whereas receptor blockade has been shown to down-modulate expression.

References: Nakamura, N., H. Hase, D. Sakurai, S. Yoshida, M. Abe, N. Tsukada, J. Takizawa, S. Aoki, M. Kojima, S. Nakamura, and Tetsuji Kobata. 2005. Expression of BAFF-R (BR3) in normal and neoplastic lymphoid tissues characterized with a newly developed monoclonal antibody, Virchows Archiv. 447: 53 - 60 [Cites use of 8A7 in IHC, flow cytometry, and Western blotting.]

Sakurai D, Kanno Y, Hase H, Kojima H, Okumura K, Kobata T. TACI attenuates antibody production costimulated by BAFF-R and CD40.Eur J Immunol. 2007 Jan;37(1):110-8. PubMed