Anti-Human CD258 (LIGHT) APC

Also known as: TNFSF14, TR2, HVEML, LTg

Clone: 7-3 (7)

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 17-2589

Cat. No.	Size
17-2589-41	25 tests
17-2589-42	100 tests
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Staining of PMA/Ionomycin-stimulated normal human peripheral blood cells with Anti-Human CD8a PE...View More

Description

Description: This 7-3 (7) monoclonal antibody reacts with human CD258 (also known as LIGHT), a 29-kDa type II transmembrane protein that is a member of the TNF ligand superfamily related to lymphotoxin-ß (LT-ß). Expressed on activated T cells, particularly CD8+ T cells, LIGHT plays a role in cell survival, inflammation, and tumor eradication. Furthermore, upon binding its ligand, herpesvirus entry mediator (HVEM), LIGHT induces a costimulatory effect on T cells, enhancing T cell proliferation and cytokine production. LIGHT has also been shown to indirectly interact with the LT-ß receptor.

Details

Host	Mouse
Isotype	IgG1, kappa
Reactivity	Human
Conjugate	APC
Laser	Red Laser
Emit	660 nm
Excite	633 - 647 nm
Reported Applications	Flow Cytometric Analysis

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
12-2589	Anti-Human CD258 (LIGHT) PE	488 - 561 nm	575 nm	FC	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
12-0088	Anti-Human CD8a PE	488 - 561 nm	575 nm	FC	RUO
17-4714	Mouse IgG1 K Isotype Control APC	633 - 647 nm	660 nm	FC	RUO

References

References: Cohavy O, Zhou J, Granger SW, Ware CF, Targan SR. LIGHT expression by mucosal T cells may regulate IFN-gamma expression in the intestine. J Immunol. 2004 Jul 1;173(1):251-8.

Mauri, D. N., R. Ebner, R. I. Montgomery, K. D. Kochel, T. C. Cheung, G. L. Yu, S. Ruben, M. Murphy, R. J. Eisenberg, G. H. Cohen, et al. LIGHT, a new member of the TNF superfamily, and lymphotoxin are ligands for herpesvirus entry mediator. 1998 Immunity 8: 21-30.

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Antigens	Area of Biology	Cell Type	Formats
CD258 (LIGHT)	Cytokines, Chemokines, Growth Factors	T Cells	APC