Anti-Human CD244 FITC

Description: The eBioPP35 monoclonal antibody reacts with human CD244, also known as 2B4, p38, NK-cell activation-inducing ligand, signaling lymphocyte activation molecule family member 4, and natural killer cell receptor 2B4. Human CD244 is a 38 kD protein expressed on NK cells, a subset of CD8+ T cells, γδ T cells, monocytes, basophils, mast cells, and eosinophils. Binding of CD244 to its ligand, CD48, results in NK cell activation. Costaining experiments with eBioC1.7 suggest that both antibodies recognize different epitopes.

References: Moretta A, Bottino C, Tripodi G, Vitale M, Pende D, Morelli L, Augugliaro R, Barbaresi M, Ciccone E, Millo R, et al. Novel surface molecules involved in human NK cell activation and triggering of the lytic machinery.Int J Cancer Suppl. 1992;7:6-10. (PP35, mAb development, FA, PubMed)

Parolini S, Bottino C, Falco M, Augugliaro R, Giliani S, Franceschini R, Ochs HD, Wolf H, Bonnefoy JY, Biassoni R, Moretta L, Notarangelo LD, Moretta A. X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells.J Exp Med. 2000 Aug 7;192(3):337-46. (PP35, FC, FA, PubMed)

Sivori S, Falco M, Marcenaro E, Parolini S, Biassoni R, Bottino C, Moretta L, Moretta A. Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation.Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4526-31. (PP35, FC, PubMed)