Anti-Human CD221 (Insulin-like Growth Factor-1 Receptor) Alexa Fluor® 488

Also known as: IGF1R

Clone: 1H7

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 53-8849

Cat. No.	Size
53-8849-41	25 tests
53-8849-42	100 tests
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Staining of HeLa cells with Mouse IgG1 K Isotype Control Alexa Fluor® 488 (cat. 53-4714) (blue...View More

Description

Description: This 1H7 monoclonal antibody reacts with human insulin-like growth factor-1 receptor (IGF-1R), also known as CD221. This receptor is a cell surface-expressed glycoprotein composed of two extracellular alpha subunits and two transmembrane beta subunits that possess tyrosine kinase activity. Expressed on nearly all cell types, this receptor binds IGF-I and IGF-II, as well as insulin. Ligand binding leads to activation of the PI3K/Akt and MAPK pathways, which mediate cell proliferation and survival. Many tumors and transformed cells display altered IGF-1R expression.

This monoclonal antibody has been reported to block binding of IGF-I and IGF-II to the IGF-1R.

Details

Host	Mouse
Isotype	IgG1, kappa
Reactivity	Human
Conjugate	Alexa Fluor 488
Laser	Blue Laser
Emit	519 nm
Excite	488 nm
Legal	Alexa Fluor® is a registered trademark of and licensed under patents assigned to Molecular Probes, Inc. for research use only. This product is subject to an agreement between Molecular Probes, Inc. and eBioscience, and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications and corresponding foreign equivalents, owned by Molecular Probes, Inc. (a wholly owned subsidiary of Invitrogen Corp). The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product for life science research or as an ASR. The buyer cannot use this product for manufacturing or for any other screening (specifically including use in combination with microarrays or High Content Screening) or testing purpose, other than as an ASR. For information on purchasing a license to this product for purposes other than life science research or use as an ASR, contact Molecular Probes, Inc.
Reported Applications	Flow Cytometric Analysis

Documentation

For complete product information, please download the TDS or IFU document.

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
16-8849	Anti-Human CD221 (Insulin-like Growth Factor-1 Receptor) Functional Grade Purified			FC, FA	RUO
17-8849	Anti-Human CD221 (Insulin-like Growth Factor-1 Receptor) APC	633 - 647 nm	660 nm	FC	RUO

References

References: Chitnis MM, Yuen JS, Protheroe AS, Pollak M, Macaulay VM. The type 1 insulin-like growth factor receptor pathway. Clin Cancer Res. 2008 Oct 15;14(20):6364-70. Review.

Li SL, Kato J, Paz IB, Kasuya J, Fujita-Yamaguchi Y. Two new monoclonal antibodies against the alpha subunit of the human insulin-like growth factor-I receptor. Biochem Biophys Res Commun. 1993 Oct 15;196(1):92-8. (1H7, WB)

Reiss K, Porcu P, Sell C, Pietrzkowski Z, Baserga R. The insulin-like growth factor 1 receptor is required for the proliferation of hemopoietic cells. Oncogene. 1992 Nov;7(11):2243-8.

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CD221 (Insulin-like Growth Factor-1 Receptor)	Cytokines, Chemokines, Growth Factors Angiogenesis	Alexa Fluor 488	New Products