Anti-Human CD218a (IL-18 Receptor alpha) PE

Description: The H44 antibody reacts with the interleukin-18 receptor alpha chain, also known as IL-1Rrp, an IL-1R family member. IL-18R alpha is expressed on Th1 cells, NK cell subset, neutrophils and IL-12-stimulated tonsillar B cells. By itself, IL-18R alpha binds IL-18 with low affinity and when complexed with IL-18R beta chain binds IL-18 with high affinity. The proinflammatory cytokine IL-18 and its receptor complex play an important role in the innate and autoimmune responses.

References: Fujimori Y, Yoshimoto T, et al. Increased expression of interleukin-18 receptor on T lymphocytes in patients with acute graft-versus-host disease after allogeneic bone marrow transplantation. J Interferon Cytokine Res2002 22:751

Gerdes N, Sukhova GK, et al. Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis. J Exp Med. 2002 195:245.

Leung BP, Culshaw S, et al. A role for IL-18 in neutrophil activation. J Immunol 2001. 167:2879

Chan, W. L., N. Pejnovic, et al. Human IL-18 receptor and ST2L are stable and selective markers for the respective type 1 and type 2 circulating lymphocytes. J. Immunol. 2001 167:1238

Nakahira M, Tomura M, et al. An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex. J Immunol. 2001 167:1306

Tominaga, K., T. Yoshimoto, et al. IL-12 synergizes with IL-18 or IL-1 beta for INF-gamma production from human T cells. Int. Immunol. 2000 12:151.