CD21 eFluor® 450

Description: The HB5 monoclonal antibody reacts with human CD21, an approximately 145 kDa type I transmembrane protein. CD21 is expressed by mature B cells, follicular dendritic cells and a subset of epithelial cells. It is a receptor for complement component C3d and Epstein-Barr virus (EBV). CD21, in association with CD19 and CD81, participates in the multimolecular complex with the B cell receptor (BCR) and is involved in B cell activation.

References: Procedures for the Collection of Diagnostic Blood Specimens by Venipuncture (H3-A6), 3rd Edition published by the National Committee for Clinical Laboratory Standards.

Tedder TF, Clement LT, Cooper MD. Expression of C3d receptors during human B cell differentiation: Immunofluorescence analysis with the HB-5 monoclonal antibody. J. Immunol. 1984; 133:678-683.

Tedder TF, Clement LT, Weis JJ, Fearon DT, Cooper MD. The C3d receptor identified by the HB-5 monoclonal antibody: Expression and Role as a receptor for Epstein-Barr virus. Leukocyte Typing II. 1986; 2:499-508.